Arqule

Search Available Compounds by Structure

List Your Company
Advertise Here
Submit Press Release

SEARCH Bio Expo Online

Home News Search Register Login



Arqule

ArQule is a biotechnology company engaged in the research and development of cancer therapeutics. Our mission is to research, develop, and commercialize broadly effective cancer drugs with reduced toxicities compared to conventional cancer chemotherapeutics. ArQule develops cancer therapies based on our innovative and proprietary Activated Checkpoint TherapySM (ACTSM) platform by applying a unique molecular biology approach that leverages automated chemistries and intelligent drug design.

The ACTSM platform is designed to produce small molecule compounds that selectively kill cancer cells while leaving normal cells unharmed. Based on the knowledge that cancer cells fail to adequately respond to cell damage, ACTSM is intended to restore and activate the proofreading mechanism by which cells respond to this damage, and consequently initiate apoptosis (cell suicide). Unlike conventional chemotherapy, ArQule’s ACTSM platform bypasses the need to create further damage to cells, by directly activating the cancer cell checkpoints. The intended result is a less toxic class of drugs that will be more effective across multiple cancer types than chemotherapy.

Our most advanced drug candidate, ARQ 501, entered Phase 1 clinical development in September 2003, for cancer patients with solid tumors. Additional ACTSM research programs are in varying stages of preclinical discovery and development. ARQ 501 is the most advanced candidate from our E2F modulation program, which we are developing in partnership with Roche.

ArQule has made a strong commitment to basic research and the programs in our pipeline are the direct result of our internal discovery efforts. As we have done since 1993, ArQule continues to provide high-quality library design and compound production to pharmaceutical collaborators. Our largest collaboration is with Pfizer and extends through 2008. The cash flow from our chemistry services offsets the cost of our internal cancer drug discovery and development programs.

Contact information:

Country:United States
State:Massachusetts
City:Woburn
Telephone number:781-994-0300
Web page:http://www.arqule.com/
Email:Contact us now

Category List

A to Z Company List
Allied Services
Building Blocks
cGMP
Software
Company Type
Contract Research, Procurement Services
Custom Synthesis
Logistics, Packaging, Shipping
Name Reactions
Natural Products
Process Services
Regional
Scientific Equipment
Screening Compounds
Specialty Chemicals
Volume Capacity
Web Links
Conferences and Trade Shows

News and Events

Media Partners
Become a Partner



Our Services
Advertisement on BioExpoonline.com
Contact BioExpoOnline
Link to BioExpoOnline
Media Partners
Partner with BioExpoOnline
Privacy and Terms of Use

Featured Links

MyriaScreen
LOPAC 1280™
Search by Structure
Bioscreening News
Chemical Reagents
Chemistry Software
Chemistry Databases

Home | News | Advanced Search | List Your Company | Advertising | Terms | Account Login | Contact Us

© 2004-2007 BioScreening.com, All Rights Reserved